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Offline kullatiro

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Maccha (matcha) green tea powder
« on: 08 December 2013, 07:54:34 PM »
Matcha ( 抹茶? , pronounced [mat.tɕa] ), also spelled maccha, refers to finely milled or fine powder green tea .

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 Matcha can now be found in numerous health food products ranging from cereal to energy bars. In 2003, researchers from the University of Colorado found that the concentration of the antioxidant EGCG available from drinking matcha is at least three times greater than the amount of EGCG available from other commercially available green teas. Matcha is also said to boost metabolism and help reduce cholesterol levels when
it is drunk regularly.  The aforementioned health benefits of matcha green tea can largely be attributed to the fact that the whole tea leaf is ingested, as opposed to just the steeped water in the case of 'bagged' green teas. This means that it delivers a much higher potency of catechins, chlorophyll, and antioxidants By weight, matcha contains several dozen times more antioxidants (> 1000
mmol/100g) than blueberries (~9mmol/100g), wolfberries pomegranates , orange juice, spinach (~1mmol/100g) or dark chocolate (~11mmol/100g).

There evidence from clinical studies that suggests that theanine , when consumed by drinking Japanese green teas, may help to reduce or moderate mental stress
responses.

http://en.m.wikipedia.org/wiki/Matcha

Peringatan matcha tidak boleh di minum oleh ibu yang sedang hamil, karena mengandung EGCG yang lebih tinggi di banding lain nya (menekan factor pertumbuhan).
« Last Edit: 08 December 2013, 08:16:53 PM by kullatiro »

Offline kullatiro

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EGCG ( Epigallocatechin gallate)
« Reply #1 on: 08 December 2013, 08:10:32 PM »
Epigallocatechin gallate (EGCG), also known as epigallocatechin-3-gallate, is the ester of epigallocatechin and gallic acid , and is a type of catechin. EGCG is the most abundant catechin in tea and is a potent antioxidant that may have therapeutic applications in the treatment of many disorders (e.g. cancer). It is found in green tea, but not black tea ; during black tea production, the catechins are converted to theaflavins and thearubigins.[3] It is also found in various vegetables, nuts, as well as carob powder at 109 mg per 100g. [4] In a high
temperature environment, an epimerization change is more likely to occur; however as exposure to boiling water for 30 straight minutes leads to only a 12.4% reduction in the total amount of EGCG, the amount lost in a brief exposure is insignificant. In fact, even when special conditions were used to create temperatures well above that of boiling water, the amount lost increased only slightly.

EGCG can be found in many supplements.

 Pharmacology

EGCG is an inhibitor of the enzymes:

Histone acetyltransferase[6]

DNA methyltransferase [7]

Fatty acid synthase [8]

Glutamate dehydrogenase [9]

Topoisomerase I and II [10]

and antagonises the Epidermal growth factor receptor 1 and Epidermal growth factor receptor 2.
[11]


 Research on potential therapeutic
uses



EGCG has been the subject of a
number of studies investigating its
potential use as a therapeutic for a
broad range of disorders:


HIV

A large amount of research has been conducted investigating the benefit of EGCG from green tea in the treatment of HIV infection, where EGCG has been shown to reduce plaques related to AIDS-related dementia in the laboratory, as well as block gp120 . [12][13][14] However, these effects have yet to be
confirmed in live human trials, and it does not imply that green tea will cure or block HIV infection, but it may help regulate viral load as long as it is not involved in adverse drug reactions. The concentrations of EGCG used in the studies could not be reached by drinking green tea. More study into EGCG and HIV is currently underway. [15]

Cancer
There is increasing evidence to show that EGCG – along with other flavonoids – can be beneficial in treating brain, [16] prostate,[17][18] cervical[19] and bladder[20] cancers.
EGCG has been shown to bind and inhibit the anti-apoptotic protein Bcl-xl ,[21] which has been implicated in both cancer cell and normal cell survival.[22]

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Neurodegeneration
EGCG is a natural chelator and has been shown to reduce iron- accumulation in instances of neurodegenerative diseases like dementia, Alzheimer's , and Parkinson's . [29] Parc de Salut Mar and Instituto Hospital del Mar de Investigaciones Médicas in Spain are conducting a clinical trial of EGCG as a potential treatment for intellectual impairment in people with Down Syndrome and Fragile X [30]


 Drug interactions
A study using mouse models at the University of Southern California showed that, in contrast to the myriad benefits commonly associated with green tea and green tea extract (GTE), EGCG binds with the anti- cancer drug Velcade, significantly reducing its bioavailability and thereby rendering it therapeutically useless.[33] Schönthal, who headed the study, suggests that
consumption of green tea and GTE products be strongly contraindicated for patients undergoing treatment for multiple myeloma and mantle cell lymphoma. [33] EGCG may reduce the bioavailability of the drug sunitinib when they are taken together. [34] EGCG was also found to induce apoptosis in endometrial
carcinoma cell line (Ishikawa cells and human primary endometrial carcinoma cells) via ROS generation and p-38 activation.



http://en.m.wikipedia.org/wiki/Epigallocatechin_gallate
« Last Edit: 08 December 2013, 08:28:38 PM by kullatiro »

 

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